Experimental validation of a mean systemic pressure analog against zero-flow measurements in porcine VA-ECMO-Reference-Cited by-同舟云学术

Experimental validation of a mean systemic pressure analog against zero-flow measurements in porcine VA-ECMO

Published:2022-03-01 Issue:3 Volume:132 Page:726-736
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Werner-Moller Per¹²^ORCID,Heinisch Paul Philipp³⁴^ORCID,Hana Anisa¹⁵,Bachmann Kaspar F.¹⁶,Sondergaard Soren⁷^ORCID,Jakob Stephan M.¹^ORCID,Takala Jukka¹,Berger David¹^ORCID

Affiliation:

1. Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

2. Department of Anesthesia, Surgery and Intensive Care, SV Hospital Group, Alingsas, Institute of Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

3. Department of Cardiovascular Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

4. Department of Congenital and Pediatric Heart Surgery, German Heart Center Munich, Technische Universität München, Munich, Germany

5. Department of Intensive Care Medicine, Laurentius Hospital, Roermond, The Netherlands

6. Centre for Intensive Care Medicine, Cantonal Hospital Lucerne, Lucerne, Switzerland

7. Department of Intensive Care and Neurointensive Stepdown Unit, Elective Surgery Centre, Silkeborg Regional Hospital, Silkeborg, Denmark

Abstract

This is the first study ever to validate the mean systemic pressure analog (Pmsa) against the reference mean systemic filling pressure (MSFP) determined at full arterio-venous pressure equilibrium. Using a porcine ECMO model with clinically relevant levels of vasoconstriction and volume expansion, we showed that Pmsa accurately estimated absolute and changing values of MSFP, with a poor between-method precision. The within-method precision of Pmsa was excellent.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00804.2021

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