Affiliation:
1. Department of Pathology, University of Helsinki, FIN-00014 Helsinki; Aurora Hospital, FIN-00029 Helsinki; and Rheumatism Foundation Hospital, FIN-18120 Heinola, Finland
Abstract
The colloid or protein osmotic pressure (Π) is a function of protein molarity (linear) and of Donnan and other effects. Albumin is the major osmotic protein, but also globulins influence Π. Equations based on concentrations of albumin and nonalbumin (globulin concentration + fibrinogen concentration) protein approximate Π better than albumin alone. Globulins have a wide range of molecular weights, and a 1956 diagram indicated that Π of globulin fractions decreased in the order α1-, α2-, β-, and γ-globulin. The molecular weight of the serum protein fractions had been extrapolated, so van't Hoff's law and nonlinear regression analysis of the curves permitted expression of the diagram as an equation: [Formula: see text], where Πs,Ott,2°C,cmH2O is Π of serum at 2°C (in cmH2O) computed from the 1956 diagram, Ctot is the concentration (g/l) of total protein in serum, and xalb, xα1, xα2, xβ, and xγ are the fractions of albumin, α1-, α2-, β-, and γ-globulin, respectively. At one and the same concentration of fractions, Π“Ott” decreases in the order α1-globulin, albumin, α2-globulin, β-globulin, and γ-globulin.
Publisher
American Physiological Society
Subject
Physiology (medical),Physiology
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