Hypoglossal nerve stimulation in a rabbit model of obstructive sleep apnea reduces apneas and improves oxygenation-Reference-Cited by-同舟云学术

Hypoglossal nerve stimulation in a rabbit model of obstructive sleep apnea reduces apneas and improves oxygenation

Published:2020-09-01 Issue:3 Volume:129 Page:442-448
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Schiefer Matthew¹²³,Gamble Jenniffer¹²,Baskin Jonathan¹²,Strohl Kingman¹²^ORCID

Affiliation:

1. Louis Stokes Cleveland Veterans Affairs Medical Center, Veterans Affairs Northeast Ohio Healthcare System, Cleveland, Ohio

2. Case Western Reserve University, Cleveland, Ohio

3. Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida

Abstract

This report describes a rabbit model for testing the impact of hypoglossal nerve stimulation (HNS) on obstructive apneas. Obstructive sleep apnea (OSA) is induced by injecting hyaluronic acid (as a filler) into the base of the tongue. HNS reduced the length and rate of obstructions and improved oxygenation during sleep. Our efforts with this model advanced understanding of the complexities of this OSA preclinical model for neurostimulation reversal of sleep-disordered breathing.

Funder

National Insitutes of Health-SPARC program

VA Rehabilitation Research Service

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00828.2019

Reference27 articles.

1. Origin, Course and Distribution of the Hypoglossal Nerve in the New Zealand Rabbit (Oryctolagus cuniculus L)

2. Reversibility of Airflow Obstruction by Hypoglossus Nerve Stimulation in Anesthetized Rabbits