Cyclooxygenase products contribute to the exaggerated exercise pressor reflex evoked by static muscle contraction in male UCD-type 2 diabetes mellitus rats-Reference-Cited by-同舟云学术

Cyclooxygenase products contribute to the exaggerated exercise pressor reflex evoked by static muscle contraction in male UCD-type 2 diabetes mellitus rats

Published:2024-05-01 Issue:5 Volume:136 Page:1226-1237
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Samora Milena¹^ORCID,Huo Yu¹,Stanhope Kimber L.²,Havel Peter J.²,Kaufman Marc P.³,Harrison Michelle L.¹^ORCID,Stone Audrey J.¹^ORCID

Affiliation:

1. Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, Texas, United States

2. Department of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition, University of California Davis, Davis, California, United States

3. Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania, United States

Abstract

We compared the pressor and cardioaccelerator responses to static muscle contraction before and after inhibition of cyclooxygenase (COX) activity within the contracting hindlimb in decerebrate, unanesthetized type 2 diabetic mellitus (T2DM) and healthy rats. The pressor responses to muscle contraction were attenuated after peripheral inhibition of COX activity in T2DM but not in healthy rats. We concluded that COX products partially contribute to the exaggerated pressor reflex in those with T2DM.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00879.2023

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