Role of parvalbumin in fatigue-induced changes in force and cytosolic calcium transients in intact single mouse myofibers-Reference-Cited by-同舟云学术

Role of parvalbumin in fatigue-induced changes in force and cytosolic calcium transients in intact single mouse myofibers

Published:2022-04-01 Issue:4 Volume:132 Page:1041-1053
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Nogueira Leonardo¹^ORCID,Gilmore Natalie K.¹,Hogan Michael C.¹

Affiliation:

1. Section of Physiology, Division of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of California, San Diego, California

Abstract

Parvalbumin (PV) is a cytosolic Ca2+ buffer that is present in mouse myofibers but not in human muscle. We show that inducible knockout of PV leads to increases in myofiber cytosolic free Ca2+ concentrations and slowing of Ca2+ pumping during fatigue versus control mice. However, PV ablation does not interfere with fatigue-induced slowing in relaxation or fatigue resistance. These data support the use of mouse muscle as a suitable model to investigate human muscle fatigue.

Funder

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Tobacco-Related Disease Research Program

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00861.2021

Reference43 articles.

1. Cellular mechanisms of muscle fatigue