Recruitment order of motor neurons promoted by epidural stimulation in individuals with spinal cord injury

Author:

Ibáñez Jaime12,Angeli Claudia A.345,Harkema Susan J.3456,Farina Dario1ORCID,Rejc Enrico36ORCID

Affiliation:

1. Department of Bioengineering, Imperial College London, London, UK

2. Department of Clinical and Movement Neurosciences, Institute of Neurology, University College London, London, UK

3. Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, Kentucky

4. Department of Bioengineering, University of Louisville, Louisville, Kentucky

5. Frazier Rehabilitation Institute, University of Louisville Health, Louisville, Kentucky

6. Department of Neurological Surgery, University of Louisville, Louisville, Kentucky

Abstract

After motor complete spinal cord injury, the human spinal cord receiving epidural stimulation can promote both orderly and inverse trends of motor neuron recruitment. The engagement of spinal networks involved in the generation of rhythmic activity seems to favor orderly recruitment trends.

Funder

HHS | National Institutes of Health

Kessler Foundation

Leona M. and Harry B. Helmsley Charitable Trust

Christopher and Dana Reeve Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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