Type 2 diabetes exacerbates changes in blood pressure-independent arterial stiffness: cross-sectional and longitudinal evidence from the SUMMIT study-Reference-Cited by-同舟云学术

Type 2 diabetes exacerbates changes in blood pressure-independent arterial stiffness: cross-sectional and longitudinal evidence from the SUMMIT study

Published:2024-01-01 Issue:1 Volume:136 Page:13-22
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Aizawa Kunihiko¹^ORCID,Gates Phillip E.¹,Mawson David M.¹,Casanova Francesco¹,Gooding Kim M.¹,Hope Suzy V.¹,Goncalves Isabel²³,Nilsson Jan²,Khan Faisel⁴,Colhoun Helen M.⁵^ORCID,Natali Andrea⁶,Palombo Carlo⁷^ORCID,Shore Angela C.¹

Affiliation:

1. Diabetes and Vascular Medicine Research Centre, NIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, United Kingdom

2. Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden

3. Department of Cardiology, Skåne University Hospital, Malmö, Sweden

4. Division of Systems Medicine, University of Dundee, Dundee, United Kingdom

5. Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom

6. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

7. Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy

Abstract

We demonstrate in this study a greater BP-independent arterial stiffness β0 in people with type 2 diabetes (T2DM) compared to those without, and also a greater change in β0 over 3 yr in people with T2DM than those without. These findings suggest that the intrinsic properties of the arterial wall may change in a different and more detrimental way in people with T2DM and likely represents accumulation of cardiovascular risk.

Funder

European Union's seventh Framework Programme

Swedish Foundation of Strategic Research

Strategic Research Area Exodiab

DH | National Institute for Health Research

Vetenskapsrådet

Hjärt-Lungfonden

Skåne University Hospital Foundations

Lund University Diabetes Center - Industrial Research Center

Publisher

American Physiological Society

Subject