Age-associated reductions in cardiovagal baroreflex sensitivity are exaggerated in middle-aged and older men with low testosterone-Reference-Cited by-同舟云学术

Age-associated reductions in cardiovagal baroreflex sensitivity are exaggerated in middle-aged and older men with low testosterone

Published:2022-08-01 Issue:2 Volume:133 Page:403-415
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Babcock Matthew C.¹²^ORCID,DuBose Lyndsey E.¹²^ORCID,Hildreth Kerry L.¹^ORCID,Stauffer Brian L.³⁴^ORCID,Cornwell William K.³,Kohrt Wendy M.¹²,Moreau Kerrie L.¹²^ORCID

Affiliation:

1. Division of Geriatric Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado

2. Veterans Affairs Eastern Colorado Geriatric Research, Educational and Clinical Center, Denver, Colorado

3. Division of Cardiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado

4. Division of Cardiology, Denver Health Medical Center, Denver, Colorado

Abstract

Middle-aged/older men with low testosterone have accelerated reductions in cardiovagal BRS compared with middle-aged/older men with normal testosterone. Increased concentrations of the proinflammatory cytokine IL-6 appear to contribute to the reductions in cardiovagal BRS in men with low testosterone.

Funder

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute on Aging

Veterans Administration Medical Center

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00245.2022

Reference80 articles.