Affiliation:
1. Institute for Environmental Medicine and the Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
Abstract
The Comroe lecture on which this review is based described my research path during the past 45 years, beginning with studies of oxidant stress (hyperoxia) and eventuating in the discovery of a synthetic inhibitor of phospholipase A2activity (called MJ33) that prevents acute lung injury in mice exposed to lipopolysaccharide. In between were studies of lung ischemia, lung surfactant metabolism, the protein peroxiredoxin 6 and its phospholipase A2activity, and mechanisms for NADPH oxidase activation. These seemingly unrelated research activities provided the nexus for identification of a novel target and a potentially novel therapeutic agent for prevention or treatment of acute lung injury.
Publisher
American Physiological Society
Subject
Physiology (medical),Physiology
Cited by
3 articles.
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