Exercise reduces the protein abundance of TXNIP and its interacting partner REDD1 in skeletal muscle: potential role for a PKA-mediated mechanism-Reference-Cited by-同舟云学术

Exercise reduces the protein abundance of TXNIP and its interacting partner REDD1 in skeletal muscle: potential role for a PKA-mediated mechanism

Published:2022-02-01 Issue:2 Volume:132 Page:357-366
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Chaves Alec B.¹^ORCID,Miranda Edwin R.²^ORCID,Mey Jacob T.³^ORCID,Blackburn Brian K.⁴,Fuller Kelly N. Z.⁵,Stearns Blaise²,Ludlow Andrew²,Williamson David L.⁶,Houmard Joseph A.¹,Haus Jacob M.²^ORCID

Affiliation:

1. Human Performance Laboratory, Department of Kinesiology, East Carolina University, Greenville, North Carolina

2. School of Kinesiology, University of Michigan, Ann Arbor, Michigan

3. Integrated Physiology and Molecular Metabolism, Pennington Biomedical Research Center, Baton Rouge, Louisiana

4. Applied Health Sciences and Kinesiology, Humboldt State University, Arcata, California

5. Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas

6. School of Behavioral Sciences and Education, Penn State University Harrisburg, Middletown, Pennsylvania

Abstract

Aerobic exercise is an effective tool in the prevention and treatment of several chronic metabolic diseases. However, the mechanisms through which these benefits are conferred have yet to be fully elucidated. Our data reveal a novel effect of aerobic exercise on reducing the protein expression of molecular targets that negatively impact redox and insulin/growth signaling in skeletal muscle. These findings contribute to the expanding repository of molecular signatures provoked by aerobic exercise.

Funder

American College of Sports Medicine

American Diabetes Association Research Foundation

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Center for Research Resources

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00229.2021

Reference42 articles.