ATP and acetylcholine interact to modulate vascular tone and α1-adrenergic vasoconstriction in humans-Reference-Cited by-同舟云学术

ATP and acetylcholine interact to modulate vascular tone and α1-adrenergic vasoconstriction in humans

Published:2021-08-01 Issue:2 Volume:131 Page:566-574
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Terwoord Janée D.¹^ORCID,Racine Matthew L.¹,Hearon Christopher M.¹,Luckasen Gary J.²,Dinenno Frank A.¹

Affiliation:

1. Human Cardiovascular Physiology Laboratory, Department of Health and Exercise Science, Colorado State University, Fort Collins, Colorado

2. Medical Center of the Rockies Foundation, University of Colorado Health, Loveland, Colorado

Abstract

The results of this study highlight the vascular endothelium as a critical site for integration of vasomotor signals in humans. For the first time, to our knowledge, we demonstrate that combined stimulation of the endothelium with ATP and ACh results in enhanced vasodilation compared with combination of either ATP or ACh with an endothelium-independent dilator. Furthermore, we show that ATP and ACh interact to modulate α1-adrenergic vasoconstriction in human skeletal muscle in vivo.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00205.2021

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