The duration of withdrawal affects the muscarinic signaling in the nucleus accumbens after chronic morphine exposure in neonatal rats-Reference-Cited by-同舟云学术

The duration of withdrawal affects the muscarinic signaling in the nucleus accumbens after chronic morphine exposure in neonatal rats

Published:2021-06-01 Issue:6 Volume:125 Page:2228-2236
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Jiang Xiao¹²³,Zhang Jian-Jun¹²^ORCID,Song Sen⁴,Li Yonghui¹²,Sui Nan¹²

Affiliation:

1. CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, People’s Republic of China

2. Department of Psychology, University of Chinese Academy of Sciences, Beijing, People’s Republic of China

3. Department of Medical Psychology, School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, People’s Republic of China

4. Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, People’s Republic of China

Abstract

We investigated for the first time how the duration of withdrawal affects mAChRs functions in the nucleus accumbens in neonatal rats. Compared with short-term withdrawal time, rats showed downregulation of presynaptic and post/extrasynaptic mAChRs functions during long-term withdrawal time. Our finding introduces a new possible correlation between the mAChRs dysfunction in the nucleus accumbens and the development of withdrawal in neonates.

Funder

The national basic research program grants

The National natural science foundation grants

The national natural science foundation grants

Key laboratory of mental health, Institute of Psychology, CAS

Chinese Academy of Sciences

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00441.2020