Cardiac myosin motor deficits are associated with left ventricular dysfunction in human ischemic heart failure-Reference-Cited by-同舟云学术

Cardiac myosin motor deficits are associated with left ventricular dysfunction in human ischemic heart failure

Published:2023-02-01 Issue:2 Volume:324 Page:H198-H209
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Rasicci D. V.¹²^ORCID,Ge J.¹,Milburn G. N.³^ORCID,Wood N. B.⁴,Pruznak A. M.¹,Lang C. H.¹,Previs M. J.⁴^ORCID,Campbell K. S.³⁵^ORCID,Yengo C. M.¹^ORCID

Affiliation:

1. Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania

2. Department of Pathology, Anatomy, and Laboratory Medicine, West Virginia University School of Medicine, Morgantown, West Virginia

3. Department of Physiology, University of Kentucky, Lexington, Kentucky

4. Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont

5. Division of Cardiovascular Medicine, University of Kentucky, Lexington, Kentucky

Abstract

Ischemic heart failure is associated with impairments in contractile performance of the heart. This study revealed that cardiac myosin isolated from patients with ischemic heart failure had reduced mechanical activity, which correlated with the impaired clinical phenotype of the patients. The results suggest that restoring myosin function with pharmacological intervention may be a viable method for therapeutic intervention.

Funder

HHS | NIH | National Institute on Alcohol Abuse and Alcoholism

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00272.2022

Reference54 articles.

1. Pathophysiology of heart failure

2. Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study

3. Significance of Ischemic Heart Disease in Patients With Heart Failure and Preserved, Midrange, and Reduced Ejection Fraction

4. Reduced cardiac myofibrillar Mg-ATPase activity without changes in myosin isozymes in patients with end-stage heart failure

5. Changes in myofibrillar content and Mg-ATPase activity in ventricular tissues from patients with heart failure caused by coronary artery disease, cardiomyopathy, or mitral valve insufficiency.