Membrane proteomic profiling of the heart: past, present, and future

Author:

Lee Shin-Haw12,Kim Da Hye12ORCID,Kuzmanov Uros12,Gramolini Anthony O.12

Affiliation:

1. Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, Toronto, Ontario, Canada

2. Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Abstract

Cardiovascular diseases remain the most rapidly rising contributing factor of all-cause mortality and the leading cause of inpatient hospitalization worldwide, with costs exceeding $30 billion annually in North America. Cell surface and membrane-associated proteins play an important role in cardiomyocyte biology and are involved in the pathogenesis of many human heart diseases. In cardiomyocytes, membrane proteins serve as critical signaling receptors, Ca2+ cycling regulators, and electrical propagation regulators, all functioning in concert to maintain spontaneous and synchronous contractions of cardiomyocytes. Membrane proteins are excellent pharmaceutical targets due to their uniquely exposed position within the cell. Perturbations in cardiac membrane protein localization and function have been implicated in the progression and pathogenesis of many heart diseases. However, previous attempts at profiling the cardiac membrane proteome have yielded limited results due to poor technological developments for isolating hydrophobic, low-abundance membrane proteins. Comprehensive mapping and characterization of the cardiac membrane proteome thereby remains incomplete. This review will focus on recent advances in mapping the cardiac membrane proteome and the role of novel cardiac membrane proteins in the healthy and the diseased heart. Listen to this article's corresponding podcast at https://ajpheart.podbean.com/e/membrane-proteomic-profiling-of-the-heart/ .

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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