Racial and socioeconomic disparity associates with differences in cardiac DNA methylation among men with end-stage heart failure-Reference-Cited by-同舟云学术

Racial and socioeconomic disparity associates with differences in cardiac DNA methylation among men with end-stage heart failure

Published:2021-05-01 Issue:5 Volume:320 Page:H2066-H2079
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Pepin Mark E.¹²^ORCID,Ha Chae-Myeong¹^ORCID,Potter Luke A.¹^ORCID,Bakshi Sayan¹,Barchue Joseph P.³,Haj Asaad Ayman³,Pogwizd Steven M.³,Pamboukian Salpy V.³,Hidalgo Bertha A.⁴,Vickers Selwyn M.⁵,Wende Adam R.¹^ORCID

Affiliation:

1. Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama

2. Institute for Experimental Cardiology, Heidelberg University Hospital, Heidelberg, Germany

3. Division of Cardiovascular Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama

4. Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama

5. Office of the Dean and Senior Vice President For Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama

Abstract

A bimodal signature of cardiac DNA methylation in heart failure corresponds with racial differences in all-cause mortality following mechanical circulatory support. Racial differences in promoter methylation disproportionately affect metabolic signaling pathways. Socioeconomic factors are associated with racial differences in the cardiac methylome among men with end-stage heart failure.

Funder

Alexander von Humboldt-Stiftung

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute on Minority Health and Health Disparities

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00036.2021

Reference83 articles.

1. The Limitations of Symptom-based Heart Failure Management

2. Mortality after hospital admission for heart failure: improvement over time, equally strong in women as in men

3. Multiscale characterization of heart failure

4. Genetic determinants of heart failure: facts and numbers

5. Atlas of the clinical genetics of human dilated cardiomyopathy

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Guidelines for mechanistic modeling and analysis in cardiovascular research;American Journal of Physiology-Heart and Circulatory Physiology;2024-08-01

2. A Biosocial Return to Race? Racial Differences in DOHaD and Environmental Epigenetics;The Handbook of DOHaD and Society;2024-06-30

3. Impact of Socioeconomic Status on Heart Failure;Journal of Community Hospital Internal Medicine Perspectives;2023-11-04

4. Cardiomyopathy in Asian Cohorts: Genetic and Epigenetic Insights;Circulation: Genomic and Precision Medicine;2023-10

5. Genes, environment, and African ancestry in cardiometabolic disorders;Trends in Endocrinology & Metabolism;2023-10