Conduit arterial wave reflection promotes pressure transmission but impedes hydraulic energy transmission to the microvasculature-Reference-Cited by-同舟云学术

Conduit arterial wave reflection promotes pressure transmission but impedes hydraulic energy transmission to the microvasculature

Published:2020-07-01 Issue:1 Volume:319 Page:H66-H75
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Kondiboyina Avinash¹²^ORCID,Smolich Joseph J.¹²^ORCID,Cheung Michael M. H.¹²³,Westerhof Berend E.⁴⁵^ORCID,Mynard Jonathan P.¹²³⁶^ORCID

Affiliation:

1. Heart Research, Murdoch Children’s Research Institute, Parkville, Victoria, Australia

2. Department of Pediatrics, University of Melbourne, Parkville, Victoria, Australia

3. Department of Cardiology, Royal Children’s Hospital, Parkville, Victoria, Australia

4. Cardiovascular and Respiratory Physiology, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Enschede, The Netherlands

5. Department of Pulmonary Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands

6. Department of Biomedical Engineering, University of Melbourne, Parkville, Victoria, Australia

Abstract

With aging, a reduction in the stiffness gradient between elastic and muscular arteries is thought to reduce wave reflection in conduit arteries, leading to increased pulsatile pressure transmission into the microvasculature. This assumes that wave reflection limits pressure transmission in arteries. However, using a computational model, we showed that wave reflection promotes pulsatile pressure transmission, although it does limit hydraulic energy transmission. Increased microvascular pulse pressure with aging is instead related to decreasing arterial compliance.

Funder

Department of Health, Australian Government | National Health and Medical Research Council

National Heart Foundation of Australia

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00733.2019

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