Regional transcriptomic profiling reveals immune system enrichment in nonfailing atria and all chambers of the failing human heart-Reference-Cited by-同舟云学术

Regional transcriptomic profiling reveals immune system enrichment in nonfailing atria and all chambers of the failing human heart

Published:2023-12-01 Issue:6 Volume:325 Page:H1430-H1445
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Sandstedt Mikael¹²^ORCID,Vukusic Kristina¹,Johansson Markus³^ORCID,Jonsson Marianne¹²,Magnusson Rasmus³^ORCID,Mattsson Hultén Lillemor²⁴^ORCID,Dellgren Göran⁴⁵,Jeppsson Anders⁴⁵^ORCID,Lindahl Anders¹²^ORCID,Synnergren Jane³⁴^ORCID,Sandstedt Joakim¹²

Affiliation:

1. Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

2. Region Västra Götaland, Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden

3. Department of Biology and Bioinformatics, School of Bioscience, University of Skövde, Skövde, Sweden

4. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

5. Region Västra Götaland, Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden

Abstract

The transcriptomic patterns of the four heart chambers were characterized in failing and nonfailing human hearts. Both nonfailing atria had distinct transcriptomic patterns characterized by cardiogenesis, the immune system and BMP/TGF-β, MAPK/JNK, and Wnt signaling. Failing atria and ventricles were enriched for gene sets associated with the innate and adaptive immune system. Key upstream regulators associated with heart failure were identified, including activated immune response elements, which may constitute novel therapeutic targets.

Funder

The Swedish Society of Medicine

The Gothenburg Society of Medicine

The Emelle Foundation

The Foundations of the Sahlgrenska University Hospital

The University of Skovde

The Swedish Knowledge Foundation

The Foundation Research Without Animal Experiments

The Swedish Royal Academy

Sahlgrenska University Hospital

Hjärt-Lungfonden

Publisher