Ultrasound-mediated targeted drug delivery: recent success and remaining challenges-Reference-Cited by-同舟云学术

Ultrasound-mediated targeted drug delivery: recent success and remaining challenges

Published:2013-02-01 Issue:3 Volume:304 Page:H350-H357
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Castle Jason¹,Butts Matthew¹,Healey Andrew²,Kent Kevin¹,Marino Michael¹,Feinstein Steven B.³⁴

Affiliation:

1. General Electric Global Research, Niskayuna, New York;

2. General Electric Medical Diagnostics, Oslo, Norway;

3. SonoGene LLC, Glen Ellyn, Illinois; and

4. Rush University Medical Center, Chicago, Illinois

Abstract

The potential clinical value of developing a novel, nonviral, ultrasound-directed gene and drug delivery system is immense. Investigators soon will initiate clinical trials with the goal of treating a wide variety of maladies using noninvasive, ultrasound-based technology. The ongoing, scientific validation associated with promising preclinical success portents a novel range of therapeutics. The clinical utility and eventual clinical successes await vigorous testing. This review highlights the recent successes and challenges within the field of ultrasound-mediated drug delivery.

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/ajpheart.00265.2012

Reference63 articles.

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4. Multi-Modality Safety Assessment of Blood-Brain Barrier Opening Using Focused Ultrasound and Definity Microbubbles: A Short-Term Study

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