Calcium handling dysfunction and cardiac damage following acute ventricular preload challenge in the dystrophin-deficient mouse heart-Reference-Cited by-同舟云学术

Calcium handling dysfunction and cardiac damage following acute ventricular preload challenge in the dystrophin-deficient mouse heart

Published:2023-11-01 Issue:5 Volume:325 Page:H1168-H1177
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Haffner Vivian¹,Nourian Zahra¹,Boerman Erika M.¹^ORCID,Lambert Michelle D.¹,Hanft Laurin M.¹,Krenz Maike¹²,Baines Christopher P.³²,Duan Dongsheng⁴⁵,McDonald Kerry S.¹^ORCID,Domeier Timothy L.¹⁶^ORCID

Affiliation:

1. Department of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, Missouri, United States

2. The Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, United States

3. Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, United States

4. Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, Missouri, United States

5. Department of Neurology, School of Medicine, University of Missouri, Columbia, Missouri, United States

6. Department of Medicine, School of Medicine, University of Missouri, Columbia, Missouri, United States

Abstract

The mechanisms of cardiac disease progression in muscular dystrophy are complex and poorly understood. Using a transgenic mouse model with cardiomyocyte-specific expression of the GCaMP6f Ca2+ indicator, the present study provides further support for the Ca2+-overload hypothesis of disease progression and ventricular arrhythmogenesis in muscular dystrophy.

Funder

University of Missouri System

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases

U.S. Department of Defense

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00265.2023

Reference55 articles.