The influence of barosensory vessel mechanics on the vascular sympathetic baroreflex: insights into aging and blood pressure homeostasis-Reference-Cited by-同舟云学术

The influence of barosensory vessel mechanics on the vascular sympathetic baroreflex: insights into aging and blood pressure homeostasis

Published:2020-08-01 Issue:2 Volume:319 Page:H370-H376
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Lord Rachel N.¹^ORCID,Wakeham Denis J.¹^ORCID,Pugh Christopher J. A.¹,Simpson Lydia L.²,Talbot Jack S.¹^ORCID,Lodge Freya M.³,Curry Bryony A.¹,Dawkins Tony G.¹^ORCID,Shave Rob E.¹⁴,Moore Jonathan P.²^ORCID

Affiliation:

1. Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, United Kingdom

2. Physical Activity for Health and Well-Being Centre, School of Sport, Health and Exercise Sciences, Bangor University, Bangor, United Kingdom

3. Cardiff and Vale University Health Board, University Hospital of Wales, Cardiff, United Kingdom

4. Centre for Heart, Lung, and Vascular Health, University of British Columbia Okanagan, Kelowna, Canada

Abstract

We assessed the influence of barosensory vessel mechanics (magnitude and rate of unloading and time spent unloaded) as a surrogate for baroreceptor unloading. In young men, aortic unloading mechanics are important in regulating the operating point of the vascular sympathetic baroreflex, whereas in middle-aged men, these arterial mechanics do not influence this operating point. The age-related increase in resting muscle sympathetic nerve activity does not appear to be driven by altered baroreceptor input from stiffer barosensory vessels.

Funder

None

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00265.2020

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