ASIC1a does not play a role in evoking the metabolic component of the exercise pressor reflex in a rat model of peripheral artery disease-Reference-Cited by-同舟云学术

ASIC1a does not play a role in evoking the metabolic component of the exercise pressor reflex in a rat model of peripheral artery disease

Published:2020-07-01 Issue:1 Volume:319 Page:H171-H182
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Ducrocq Guillaume P.¹^ORCID,Kim Joyce S.¹^ORCID,Estrada Juan A.¹,Kaufman Marc P.¹

Affiliation:

1. Heart and Vascular Institute, Pennsylvania State College of Medicine, Hershey, Pennsylvania

Abstract

The role of ASIC1a in evoking the metabolic component of the exercise pressor reflex in peripheral artery disease is unknown. Using a within-rat experimental design, we found that the contribution of ASIC1a decreased in a rat model of peripheral artery disease. These results have key implications to help finding better treatments and improve morbidity, quality of life, and mortality in patients with peripheral artery disease.

Funder

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases

National Heart and Lung Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00257.2020

Reference43 articles.

1. On the contribution of group III and IV muscle afferents to the circulatory response to rhythmic exercise in humans

2. Alternative Splicing and Interaction with Di- and Polyvalent Cations Control the Dynamic Range of Acid-sensing Ion Channel 1 (ASIC1)