Plexus-specific effect of flicker-light stimulation on the retinal microvasculature assessed with optical coherence tomography angiography-Reference-Cited by-同舟云学术

Plexus-specific effect of flicker-light stimulation on the retinal microvasculature assessed with optical coherence tomography angiography

Published:2021-01-01 Issue:1 Volume:320 Page:H23-H28
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Kallab Martin¹^ORCID,Hommer Nikolaus¹,Tan Bingyao²³,Pfister Martin⁴⁵⁶^ORCID,Schlatter Andreas¹⁷,Werkmeister René M.⁴^ORCID,Chua Jacqueline²⁸,Schmidl Doreen¹,Schmetterer Leopold¹²³⁴⁹,Garhöfer Gerhard¹

Affiliation:

1. Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

2. Singapore Eye Research Institute, Singapore

3. Institute of Health Technology, Nanyang Technological University, Singapore

4. Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria

5. Christian Doppler Laboratory for Ocular and Dermal Effects of Thiomers, Medical University of Vienna, Vienna, Austria

6. Institute of Applied Physics, Vienna University of Technology, Vienna, Austria

7. Department of Ophthalmology, Vienna Institute for Research in Ocular Surgery—Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria

8. Academic Clinical Program, Duke-NUS Medical School, Singapore

9. Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore

Abstract

We present vessel density alterations in response to flicker stimulation using optical coherence tomography angiography and identified the superficial capillary plexus as the layer with the most pronounced effect. This points out the physiological importance of the microvasculature in mediating functional hyperemia and suggests a fine-tuned plexus-specific mechanism to meet cellular metabolic demands.

Funder

Singapore National Medical Research Council

Austrian Science Fund

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00495.2020

Reference38 articles.

1. Glial and neuronal control of brain blood flow

2. On the Regulation of the Blood-supply of the Brain