Enhanced sympathetic neurotransduction in the superior mesenteric artery in a rat model of heart failure: role of noradrenaline and ATP-Reference-Cited by-同舟云学术

Enhanced sympathetic neurotransduction in the superior mesenteric artery in a rat model of heart failure: role of noradrenaline and ATP

Published:2021-02-01 Issue:2 Volume:320 Page:H563-H574
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Blanco-Rivero Javier¹²³⁴^ORCID,Couto Gisele K.⁴,Paula Suliana M.⁴^ORCID,Fontes Milene T.⁴,Rossoni Luciana V.⁴^ORCID

Affiliation:

1. Department of Physiology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain

2. Center for Biomedical Research Network in Cardiovascular Diseases (CiberCV), Madrid, Spain

3. Research Institute University Hospital la Paz (IdiPaz), Madrid, Spain

4. Department of Physiology and Biophysics, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo, Brazil

Abstract

This study reinforces the pivotal role of noradrenergic innervation in the regulation of mesenteric vascular tone in a rat model of heart failure. Moreover, our results highlight the counteracting role of ATP and NA reuptake, and help to understand the signaling pathways involved on the control of vascular tonus and resistance in heart failure postmyocardial infarction.

Funder

CiberCV

European Regional Development Grant (FEDER)/Comunidad de Madrid

R+D projects for young researchers

Coordenacao de Aperfcionamento de Pessoal de Nivel Superior

Becas Iberoamerica Jovenes Profesores e Investigadores

São Paulo Research Foundation

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology