Detrimental effects of transient cerebral ischemia on middle cerebral artery mitochondria in female rats

Author:

Rutkai Ibolya12ORCID,Merdzo Ivan1,Wunnava Sanjay1,McNulty Catherine1,Chandra Partha K.1ORCID,Katakam Prasad V.12,Busija David W.12

Affiliation:

1. Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana

2. Tulane Brain Institute, Tulane University, New Orleans, Louisiana

Abstract

We propose that differences in mitochondrial characteristics of males and females, including mitochondrial morphology, respiration, and calcium sparks activity contribute to sex differences in protective and repair mechanisms in response to transient ischemia-reperfusion.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute on Aging

HHS | NIH | National Institute of Neurological Disorders and Stroke

Louisiana Board of Regents

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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