BAG3 expression and sarcomere localization in the human heart are linked to HSF-1 and are differentially affected by sex and disease-Reference-Cited by-同舟云学术

BAG3 expression and sarcomere localization in the human heart are linked to HSF-1 and are differentially affected by sex and disease

Published:2021-06-01 Issue:6 Volume:320 Page:H2339-H2350
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Martin Thomas G.¹,Tawfik Sara¹,Moravec Christine S.²,Pak Toni R.¹,Kirk Jonathan A.¹^ORCID

Affiliation:

1. Department of Cell and Molecular Physiology, Loyola University Stritch School of Medicine, Maywood, Illinois

2. Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, Ohio

Abstract

Myofilament BAG3 expression decreases in male patients with nonischemic DCM but is preserved in female patients with DCM. BAG3 expression in the human heart is tightly linked to HSF-1 expression and nuclear translocation. HSF-1 localizes to the sarcomere Z-disc in the human heart. HSF-1 expression in the myofilament fraction decreases in male patients with DCM and positively correlates with myofilament BAG3.

Funder

American Heart Association

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute on Aging

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00419.2020

Reference50 articles.

1. The Multifunctional Protein BAG3