Sex differences and role of lysyl oxidase-like 2 in angiotensin II-induced hypertension in mice-Reference-Cited by-同舟云学术

Sex differences and role of lysyl oxidase-like 2 in angiotensin II-induced hypertension in mice

Published:2024-09-01 Issue:3 Volume:327 Page:H642-H659
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Wang Huilei¹,Martinez Yus Marta²^ORCID,Brady Travis¹^ORCID,Choi Rira³^ORCID,Nandakumar Kavitha³,Smith Logan¹^ORCID,Jang Rosie⁴,Wodu Bulouere Princess⁵,Almodiel Jose Diego²,Stoddart Laila¹,Kim Deok-Ho¹⁶⁷⁸^ORCID,Steppan Jochen³^ORCID,Santhanam Lakshmi¹²³⁸^ORCID

Affiliation:

1. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

2. Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, United States

3. Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

4. Department of Molecular and Cellular Biology, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, Maryland, United States

5. Department of Biology, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, Maryland, United States

6. Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

7. Department of Mechanical Engineering, Johns Hopkins University, Whiting School of Engineering, Baltimore, Maryland, United States

8. Center for Microphysiological Systems, Johns Hopkins University, Baltimore, Maryland, United States

Abstract

We examined the effect of sex on the evolution of angiotensin II (ANG II)-induced hypertension and the role of lysyl oxidase-like 2 (LOXL2), an enzyme that catalyzes matrix cross linking. While ANG II led to hypertension and worsening vascular reactivity in both sexes, aortic remodeling and stiffening occurred only in males. LOXL2 depletion improved outcomes in males but not females. Thus males and females exhibit a distinct etiology of hypertension and LOXL2 is an effective target in males.

Funder

American Heart Association

HHS | NIH | National Heart, Lung, and Blood Institute

Johns Hopkins University

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00110.2024

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