Coronary vasodilation mediated by T cells expressing choline acetyltransferase

Author:

Chester Adrian H.12ORCID,McCormack Ann1,Miller Edmund J.3ORCID,Ahmed Mohamed N.4,Yacoub Magdi H.1

Affiliation:

1. Heart Science Centre, Magdi Yacoub Institute, Harefield, United Kingdom

2. National Heart and Lung Institute, Imperial College London, London, United Kingdom

3. RDS2 Solutions, Stony Brook, New York

4. Department of Pediatrics, Steele Children’s Research Center, The University of Arizona College of Medicine, Tucson, Arizona

Abstract

This study shows ChAT-expressing T cells can induce vasodilation of the blood vessel in the coronary circulation and that this effect relies on a direct interaction between T cells and the coronary vascular endothelium. The study establishes a potential immunomodulatory role for T cells in the coronary circulation. The present findings offer an additional possibility that a deficiency of ChAT-expressing T cells could contribute to reduced coronary blood flow and ischemic events in the myocardium.

Funder

Magdi Yacoub Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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