Epigenetic regulation of intercellular communication in the heart

Author:

Segers Vincent F. M.12ORCID,Gevaert Andreas B.123ORCID,Boen Jente R. A.13,Van Craenenbroeck Emeline M.23,De Keulenaer Gilles W.14

Affiliation:

1. Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium

2. Department of Cardiology, University Hospital Antwerp, Edegem, Belgium

3. Research Group Cardiovascular Diseases, GENCOR Department, University of Antwerp, Antwerp, Belgium

4. Department of Cardiology, Ziekenhuisnetwerk Antwerpen, Hospital, Antwerp, Belgium

Abstract

The myocardium is a highly structured tissue consisting of different cell types including cardiomyocytes, endothelial cells, fibroblasts, smooth muscle cells, inflammatory cells, and stem cells. Microvascular endothelial cells are the most abundant cell type in the myocardium and play crucial roles during cardiac development, in normal adult myocardium, and during myocardial diseases such as heart failure. In the last decade, epigenetic changes have been described regulating cellular function in almost every cell type in the organism. Here, we review recent evidence on different epigenetic changes that regulate intercellular communication in normal myocardium and during myocardial diseases, including cardiac remodeling. Epigenetic changes influence many intercellular communication signaling systems, including the nitric oxide, angiotensin, and endothelin signaling systems. In this review, we go beyond discussing classic endothelial function (for instance nitric oxide secretion) and will discuss epigenetic regulation of intercellular communication.

Funder

University of Antwerp

Fonds Wetenschappelijk Onderzoek (Flemish Research Foundation)

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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