Characterization of a robust mouse model of heart failure with preserved ejection fraction-Reference-Cited by-同舟云学术

Characterization of a robust mouse model of heart failure with preserved ejection fraction

Published:2023-08-01 Issue:2 Volume:325 Page:H203-H231
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Matsiukevich Dzmitry¹²^ORCID,Kovacs Attila³,Li Tiandao¹,Kokkonen-Simon Kristen⁴,Matkovich Scot J.⁴,Oladipupo Sunday S.⁴,Ornitz David M.¹^ORCID

Affiliation:

1. Department of Developmental Biology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, United States

2. Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, Missouri, United States

3. Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, Missouri, United States

4. Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, United States

Abstract

Heart failure with preserved ejection fraction (HFpEF) is an emerging epidemic affecting up to half of patients with heart failure. Here we used a chronic angiotensin II/phenylephrine (ANG II/PE) infusion model and instituted an updated algorithm for HFpEF assessment. Given the simplicity in generating this model, it may become a useful tool for investigating pathogenic mechanisms, identification of diagnostic markers, and for drug discovery aimed at both prevention and treatment of HFpEF.

Funder

Lilly Research Award Program

Washington University Institute of Clinical and Translational Sciences

Eli Lilly and Company

HHS | NIH | National Center for Advancing Translational Sciences

Institute of Clinical and Translational Sciences

Washington University in St. Louis

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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