Increased pulse wave velocity in persons with spinal cord injury: the effect of the renin-angiotensin-aldosterone system

Author:

Katzelnick Caitlyn G.123,Weir Joseph P.4,Pinto Zipp Genevieve3,LaFountaine Michael F.1567,Bauman William A.17,Dyson-Hudson Trevor A.28,Wecht Jill M.18

Affiliation:

1. James J Peters Veterans Affairs Medical Center, Bronx, New York

2. Kessler Foundation, West Orange, New Jersey

3. Department of Interprofessional Health Sciences and Health Administration, School of Health and Medical Sciences, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey

4. Department of Health, Sport, and Exercise Sciences, University of Kansas, Lawrence, Kansas

5. Department of Physical Therapy, School of Health and Medical Sciences, Seton Hall University, South Orange, New Jersey

6. Department of Medical Sciences and Neurology, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, New Jersey

7. Icahn School of Medicine at Mount Sinai, New York City, New York

8. Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, New Jersey

Abstract

Our novel findings suggest that increased arterial stiffness in individuals with SCI may be due to greater dependency on the RAAS to maintain hemodynamic stability during an orthostatic challenge. Asymptomatic orthostatic hypotension can occur in persons with SCI during transition from the supine to the seated position and during other upright activities of daily living; however, it is seldom addressed by clinicians.

Funder

Deparment of Veterans Affairs, Veterans Health Administration, Rehabilitation Research & Development Service

New Jersey Commission on Spinal Cord Research

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The Clinical Relevance of Autonomic Dysfunction, Cerebral Hemodynamics, and Sleep Interactions in Individuals Living With SCI;Archives of Physical Medicine and Rehabilitation;2024-01

2. Item Banks for Measuring the Effect of Blood Pressure Dysregulation on Health-Related Quality of Life in Persons With Spinal Cord Injury;Archives of Physical Medicine and Rehabilitation;2023-11

3. Altered heart rate variability and pulse-wave velocity after spinal cord injury;World Journal of Clinical Cases;2022-09-26

4. Spinal cord injuries;Introduction to Clinical Aspects of the Autonomic Nervous System;2022

5. Reinforcing rigor and reproducibility expectations for use of sex and gender in cardiovascular research;American Journal of Physiology-Heart and Circulatory Physiology;2021-11-01

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