AHA/ACC-defined stage 1 hypertensive adults do not display cutaneous microvascular endothelial dysfunction-Reference-Cited by-同舟云学术

AHA/ACC-defined stage 1 hypertensive adults do not display cutaneous microvascular endothelial dysfunction

Published:2020-09-01 Issue:3 Volume:319 Page:H539-H546
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Dillon Gabrielle A.¹^ORCID,Greaney Jody L.¹²,Shank Sean¹,Leuenberger Urs A.³,Alexander Lacy M.¹

Affiliation:

1. Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania

2. Department of Kinesiology, University of Texas Arlington, Arlington, Texas

3. Department of Medicine, Pennsylvania State College of Medicine, Hershey, Pennsylvania

Abstract

This is the first study to pharmacologically assess the mechanistic regulation of endothelial function in adults with hypertension, classified according to the 2017 clinical guidelines set for by the American Heart Association (AHA) and American College of Cardiology (ACC). Compared with that in normotensive adults, nitric oxide-mediated endothelium-dependent dilation is impaired in adults with stage 2, but not stage 1, hypertension. Adults lacking a nighttime dip in blood pressure demonstrated reductions in endothelium-dependent dilation.

Funder

NIH

National Dairy Council

CTSI TL1

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00179.2020

Reference57 articles.

1. Endothelial function is impaired in the cutaneous microcirculation of adults with psoriasis through reductions in nitric oxide-dependent vasodilation