Sympathetic neural overdrive and diminished exercise capacity in reduced ejection fraction heart failure related to anthracycline-based chemotherapy-Reference-Cited by-同舟云学术

Sympathetic neural overdrive and diminished exercise capacity in reduced ejection fraction heart failure related to anthracycline-based chemotherapy

Published:2023-11-01 Issue:5 Volume:325 Page:H1126-H1132
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Rodrigues Amanda G.¹²^ORCID,Sales Allan R. K.²³⁴^ORCID,Faria Diego³⁴,Fonseca Silvia M. R.⁵,Bond Marina M. K.⁶^ORCID,Jordão Camila P.²,de Souza Francis R.²,Bittar Cristina S.⁵^ORCID,Dos Santos Marília H. H.⁵,Sarmento Adriana O.⁷,Negrao Marcelo V.⁸,Hajjar Ludhmila A.²,Negrão Carlos E.²⁹,Kalil Filho Roberto¹²

Affiliation:

1. Research and Education Institute, Hospital Sirio Libanes, São Paulo, Brazil

2. Faculdade de Medicina, Instituto do Coração, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, Brazil

3. D'Or Institute for Research and Education, São Paulo, Brazil

4. D'Or Institute for Research and Education, Rio de Janeiro, Brazil

5. Faculdade de Medicina, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Universidade de São Paulo, São Paulo, Brazil

6. Centro Paulista de Oncologia-Oncoclínicas, São Paulo, Brazil

7. Curso de Fisioterapia, Universidade Anhembi Morumbi, São Paulo, Brazil

8. Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States

9. Escola de Educação Física e Esporte, Universidade de São Paulo, São Paulo, Brazil

Abstract

Patients with heart failure with reduced ejection fraction related to anthracycline-based chemotherapy have increased sympathetic nerve activity and decreased exercise capacity. These alterations in autonomic control and physical capacity are similar to those observed in patients with heart failure due to other etiologies. These findings highlight the importance of special care of oncological patients treated with chemotherapy.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Fundação de Amparo à Pesquisa do Estado de São Paulo

D’Or Institute for Research and Education

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00476.2023

Reference29 articles.

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4. Molecular basis for the improvement in muscle metaboreflex and mechanoreflex control in exercise-trained humans with chronic heart failure

5. Increased muscle sympathetic nerve activity predicts mortality in heart failure patients

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