GPR43 regulates sodium butyrate-induced angiogenesis and matrix remodeling-Reference-Cited by-同舟云学术

GPR43 regulates sodium butyrate-induced angiogenesis and matrix remodeling

Published:2021-03-01 Issue:3 Volume:320 Page:H1066-H1079
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Castro Pollyana Ribeiro¹^ORCID,Bittencourt Lucas Felipe Fernandes¹^ORCID,Larochelle Sébastien²,Andrade Silvia Passos¹,Mackay Charles Reay³,Slevin Mark⁴,Moulin Véronique J.²⁵^ORCID,Barcelos Lucíola Silva¹

Affiliation:

1. Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil

2. Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Centre de recherche du CHU de Québec-Université Laval, Quebec, Canada

3. Department of Immunology, Monash University, Clayton, Victoria, Australia

4. School of Healthcare Science, GMBC, Manchester Metropolitan University, Manchester, United Kingdom

5. Department of Surgery, Faculty of Medicine, Université Laval, Quebec, Canada

Abstract

Our data show the contribution of the metabolite-sensing receptor GPR43 in the effects of low dose of sodium butyrate (NaBu) on stimulating angiogenesis and extracellular matrix remodeling in a model of granulation tissue formation in mice. We also show that human dermal fibroblasts, myofibroblasts, and endothelial cells express the receptor GPR43. These data provide important insights for the use of NaBu in local therapeutic approaches applicable to tissue repair in sites other than the intestine.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Pesquisa

Fundação de Amparo à Pesquisa de Minas Gerais

National Institute of Science and Technology (INCT-NanoBiofar) – Brazil

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00515.2019

Reference73 articles.