Deficiency in ST2 signaling ameliorates RSV-associated pulmonary hypertension-Reference-Cited by-同舟云学术

Deficiency in ST2 signaling ameliorates RSV-associated pulmonary hypertension

Published:2021-08-01 Issue:2 Volume:321 Page:H309-H317
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Vu Luan D.¹²³^ORCID,Saravia Jordy¹⁴⁵,Jaligama Sridhar¹⁴⁶,Baboeram Panday Rajshri V.¹,Sullivan Ryan D.⁷⁸^ORCID,Mancarella Salvatore⁹^ORCID,Cormier Stephania A.¹²³⁴,Kimura Dai¹⁴^ORCID

Affiliation:

1. Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee

2. Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana

3. Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana

4. Le Bonheur Children’s Hospital, Memphis, Tennessee

5. Department of Immunology, St. Jude Children’s Research Hospital, Memphis, Tennessee

6. IIT Research Institute, Chicago, Illinois

7. Department of Comparative Medicine, University of Tennessee Health Science Center, Memphis, Tennessee

8. Department of Internal Medicine, University of Arizona College of Medicine-Phoenix, Phoenix, Arizona

9. Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee

Abstract

We report that the pathogenic role of ST2-mediated type 2 immunity and mechanisms contribute to RSV-associated pulmonary hypertension. Inhibiting ST2 signaling may be a novel therapeutic target for this condition.

Funder

Le Bonheur Foundation

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00018.2021

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