Cardiovascular autonomic nervous function in children conceived by assisted reproductive technology with frozen or fresh embryo transfer-Reference-Cited by-同舟云学术

Cardiovascular autonomic nervous function in children conceived by assisted reproductive technology with frozen or fresh embryo transfer

Published:2024-01-01 Issue:1 Volume:326 Page:H216-H222
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Mizrak Ikram¹²^ORCID,Lund Morten A. V.³⁴,Landgrebe Ann V.⁴,Asserhøj Louise L.²⁵,Holstein-Rathlou Niels-Henrik⁴,Greisen Gorm⁶^ORCID,Clausen Tine D.⁷⁸^ORCID,Main Katharina M.⁵⁸^ORCID,Vejlstrup Niels G.⁴,Jensen Rikke B.⁵⁸,Pinborg Anja²⁸^ORCID,Madsen Per L.¹⁸

Affiliation:

1. Department of Cardiology, Herlev-Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark

2. Fertility Department, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

3. Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

4. Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

5. Department of Growth and Reproduction and EDMaRC, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

6. Department of Neonatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

7. Department of Gynecology and Obstetrics, North Zealand Hospital, Copenhagen University Hospital, Hillerød, Denmark

8. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Abstract

We observed that children conceived by assisted reproductive technology (both frozen and fresh embryo transfer) had lowered heart rate variability during rest as compared with children conceived naturally. During physiological stress maneuvers, however, the cardiovascular autonomic nervous regulation was comparable between children conceived by assisted reproductive technologies and naturally. Our findings highlight the potential that lowered heart rate variability during rest in children conceived by assisted reproductive technologies may precede premature hypertension.

Funder

The Research Foundation at Rigshospitalet

Novo Nordisk Fonden

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00680.2023

Reference30 articles.

1. Cardiovascular function in 8- to 9-year-old singletons born after ART with frozen and fresh embryo transfer

2. Postnatal persistence of fetal cardiovascular remodelling associated with assisted reproductive technologies: a cohort study

3. Cardiometabolic Differences in Children Born After in Vitro Fertilization: Follow-Up Study

4. Association of Assisted Reproductive Technologies With Arterial Hypertension During Adolescence