Relationship between LDL-cholesterol, small and dense LDL particles, and mRNA expression in a cohort of African Americans-Reference-Cited by-同舟云学术

Relationship between LDL-cholesterol, small and dense LDL particles, and mRNA expression in a cohort of African Americans

Published:2024-09-01 Issue:3 Volume:327 Page:H690-H700
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Diallo Ana¹^ORCID,Abbas Malak²,Goodney Gabriel²,Price Elvin³,Gaye Amadou⁴^ORCID

Affiliation:

1. School of Nursing, Virginia Commonwealth University, Richmond, Virginia, United States

2. National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States

3. Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University, Richmond, Virginia, United States

4. Department of Integrative Genomics and Epidemiology, School of Graduate Studies, Meharry Medical College, Nashville, Tennessee, United States

Abstract

The study investigated the interplay between LDL-C and mRNA expression, focusing on the role of small dense LDL (sdLDL) particles and sex differences. Differential expression analysis identified 1,048 and 284 mRNAs associated with LDL-C and sdLDL levels, respectively. Mediation analysis revealed that sdLDL mediates the relationship between LDL-C and 33 mRNAs involved in immune, inflammatory, and metabolic pathways. These findings highlight the significance of sdLDL in cardiovascular disease risk assessment and underscore sex-specific differences in lipid metabolism.

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00332.2024

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