Vascular ligation response is independent of p107: stressing the role of the related p130

Author:

Sindermann Jürgen R.,Köbbert Christiane,Bauer Florian,Skaletz-Rorowski Adriane,Hohage Helge,Plenz Gabriele,Breithardt Günter,March Keith L.

Abstract

Recent studies have revealed the role of the pRb family members pRb and p130 in the response to vascular injury. We evaluated the arterial injury response in the absence of p107, a protein that shares a high degree of homology with the injury-controlling p130. Carotid artery ligation and perivascular electric injury of the femoral artery were applied to p107 knockout (p107 –/–) mice, and morphometric analysis was performed 3 wk after ligation and electric injury. Arterial vessels of p107 –/– mice were indistinguishable from controls under basal conditions. After carotid artery ligation the p107 –/– mice ( n = 7) did not display an enhanced ligation response compared with controls ( n = 9), which was studied over a distance of ∼450 μm proximal and ∼200 μm distal from the ligation site, with regard to vessel wall area, neointima area, and lumen area. Corresponding with this, morphometric data obtained from the perivascular electric injury of the femoral artery confirmed the lack of enhanced ligation and injury response in the absence of p107. We conclude that the pRb family member p107 is not a key regulator in vascular injury response. These data, in conjunction with previously reported results, indicate that the control of vascular injury response is not a redundant feature of pRb proteins but primarily specific for p130. Further studies on functional domains of p130 and p107 will help to resolve the pathways in vascular injury response.

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Vascular remodeling in ApoE-deficient mice: Diet dependent modulation after carotid ligation;Atherosclerosis;2009-05

2. Vascular injury response in mice is dependent on genetic background;American Journal of Physiology-Heart and Circulatory Physiology;2006-03

3. Mechanism of eosinophil induced signaling in cholinergic IMR-32 cells;American Journal of Physiology-Lung Cellular and Molecular Physiology;2005-02

4. Eosinophil-induced release of acetylcholine from differentiated cholinergic nerve cells;American Journal of Physiology-Lung Cellular and Molecular Physiology;2003-12

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3