Beat-to-beat cardiac repolarization lability increases during hypoxemia and arousals in obstructive sleep apnea patients-Reference-Cited by-同舟云学术

Beat-to-beat cardiac repolarization lability increases during hypoxemia and arousals in obstructive sleep apnea patients

Published:2024-05-01 Issue:5 Volume:326 Page:H1094-H1104
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Ebrahimian Serajeddin¹²^ORCID,Sillanmäki Saara²³^ORCID,Hietakoste Salla¹²^ORCID,Kulkas Antti¹⁴,Töyräs Juha¹⁵⁶^ORCID,Bailón Raquel⁷⁸,Hernando David⁷⁸,Lombardi Carolina⁹¹⁰,Grote Ludger¹¹¹²,Bonsignore Maria R.¹³^ORCID,Saaresranta Tarja¹⁴¹⁵^ORCID,Pépin Jean-Louis¹⁶^ORCID,Leppänen Timo¹²⁵^ORCID,Kainulainen Samu¹²^ORCID

Affiliation:

1. Department of Technical Physics, University of Eastern Finland, Kuopio, Finland

2. Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland

3. Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland

4. Department of Clinical Neurophysiology, Seinäjoki Central Hospital, Seinäjoki, Finland

5. School of Electrical Engineering and Computer Science, The University of Queensland, Brisbane, Australia

6. Science Service Center, Kuopio University Hospital, Kuopio, Finland

7. Biomedical Signal Interpretation and Computational Simulation (BSICoS) Group, Aragón Institute of Engineering Research (I3A), IIS Aragón, University of Zaragoza, Zaragoza, Spain

8. Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain

9. IRCCS Istituto Auxologico Italiano, Department of Cardiovascular, Neural and Metabolic Sciences, Milan, Italy

10. Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy

11. Department of Sleep Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden

12. Sleep and Vigilance Laboratory, Department of Internal Medicine, University of Gothenburg, Gothenburg, Sweden

13. PROMISE Department, University of Palermo and IRIB-CNR, Palermo, Italy

14. Division of Medicine, Department of Pulmonary Diseases, Turku University Hospital, University of Turku, Turku, Finland

15. Sleep Research Centre, Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland

16. Inserm U1300, HP2 Laboratory, University of Grenoble Alpes, Grenoble, France

Abstract

Nocturnal desaturations are associated with increased ventricular repolarization lability. Deeper desaturations with accompanying arousals increase the magnitude of alterations, independent of confounding factors, comorbidities, and medications. Changes associated with desaturations can partially explain the increased risk of arrhythmias and sudden cardiac death in patients with OSA, especially in patients with high hypoxic load and fragmented sleep. This highlights the importance of detailed electrocardiogram analytics for patients with OSA.

Funder

EC | ERC | HORIZON EUROPE European Research Council

Research Committee of the Kuopio University Hospital Catchment Area for the State Research Funding

Päivikki & Sakari Sohlberg Foundation

The Research Foundation of the Pulmonary Diseases

Seinäjoki Central Hospital

Tays

Finnish Cultural Foundation

Tampere Tuberculosis Foundation

Alfred Kordelin foundation

Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina

CIBER in Bioengineering, Biomaterials & Nanomedicne (CIBERBBN) through Instituto de Salud Carlos III and FEDER