Impact of ischemia on left atrial remodeling and dysfunction in swine models of mitral regurgitation

Author:

Sakata Tomoki1ORCID,Mazurek Renata1,Mavropoulos Spyros A.1,Romeo Francisco J.1ORCID,Ravichandran Anjali J.1ORCID,Watanabe Shin1ORCID,Kariya Taro1,Ishikawa Kiyotake1ORCID

Affiliation:

1. Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York

Abstract

We show different LA structural and functional remodeling patterns between ischemic MR and MR due to leaflet prolapse. Severe ischemic MR was accompanied by extensive LA remodeling, which may be associated with poor clinical outcomes. Our data suggest that detailed structural and functional LA remodeling assessment is important for managing IMR and to determine the presence of LA ischemia.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. High-impact opportunities to address ischemia: a focus on heart and circulatory research;American Journal of Physiology-Heart and Circulatory Physiology;2022-12-01

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