Dynamics of flow, resistance, and intramural vascular volume in canine coronary circulation

Author:

Spaan Jos A. E.1,Cornelissen Annemiek J. M.2,Chan Charles2,Dankelman Jenny3,Yin Frank C. P.4

Affiliation:

1. Department of Medical Physics, Cardiovascular Research Institute Amsterdam, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands;

2. Cardiology Division, Johns Hopkins University, School of Medicine, Baltimore, MD 21287;

3. Man-Machine Systems and Control Group, Faculty of Design, Engineering and Production, Delft University of Technology, 2628 CD Delft, The Netherlands; and

4. Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130

Abstract

Varying coronary volume will vary vascular resistance and thereby have an effect on coronary hemodynamics. Six ventricular septa were isolated from anesthetized dogs, dispersed in a biaxial stretch apparatus at diastolic stress, and perfused artificially with an oxygenated perfluorochemical emulsion at maximal vasodilation. Flow and thickness were measured continuously by an electromagnetic flow probe and sonomicrometer. Pressure was varied sinusoidally around 30, 50, and 70 mmHg with an amplitude of 7.5 mmHg; frequencies ranged between 0.015 and 7 Hz. Bode plots of admittance (flow/pressure) and capacitance (scaled thickness/pressure) were constructed. A two-compartment model was used in which the resistances vary with volume. Realistic values of microvascular compliance (∼0.3 ml ⋅ mmHg−1 ⋅ 100 g−1) were found. Values 10 times higher were then found when resistances were forced to be constant. We concluded that volume dependence of resistances have to be taken into account when dynamic or static pressure-flow relations are studied and conceal the effect of a large intramyocardial compliance on arterial hemodynamics.

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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