Gαi-biased apelin analog protects against isoproterenol-induced myocardial dysfunction in rats-Reference-Cited by-同舟云学术

Gαi-biased apelin analog protects against isoproterenol-induced myocardial dysfunction in rats

Published:2021-04-01 Issue:4 Volume:320 Page:H1646-H1656
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Coquerel David¹,Delile Eugénie¹,Dumont Lauralyne¹,Chagnon Frédéric¹,Murza Alexandre²,Sainsily Xavier¹²,Salvail Dany³,Sarret Philippe²,Marsault Eric²,Auger-Messier Mannix¹^ORCID,Lesur Olivier¹

Affiliation:

1. Département de Médecine, Faculté de Médecine et des Sciences de la Santé, Institut de Pharmacologie de Sherbrooke, Centre de Recherche du CHUS, Université de Sherbrooke, Sherbrooke, Québec, Canada

2. Département de Pharmacologie et Physiologie, Faculté de Médecine et des Sciences de la Santé, Institut de Pharmacologie de Sherbrooke, Centre de Recherche du CHUS, Université de Sherbrooke, Sherbrooke, Québec, Canada

3. IPS Therapeutique Inc., Sherbrooke, Québec, Canada

Abstract

By using more potent Gαi-biased APJ agonists that strongly inhibit cAMP production, these data point to the negative inotropic effect of APJ-mediated Gαi signaling in the heart and highlight the potential protective impact of APJ-dependent Gαi signaling in cardiovascular diseases associated with left ventricular hypertrophy.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00688.2020

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3. Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor