Evaluation of early bilateral ovariectomy in mice as a model of left heart disease-Reference-Cited by-同舟云学术

Evaluation of early bilateral ovariectomy in mice as a model of left heart disease

Published:2022-06-01 Issue:6 Volume:322 Page:H1080-H1085
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Joll J. Ethan¹,Bersi Matthew R.¹^ORCID,Nyman Jeffry S.²^ORCID,Merryman W. David¹^ORCID

Affiliation:

1. Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee

2. Department of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee

Abstract

This article uses in vivo and ex vivo analysis to track the development of osteoporosis and left heart cardiovascular disease in an aged, high-cholesterol diet, mouse ovariectomy model. Mice develop early left ventricle hypertrophy without concurrent fibrosis or aortic valve stenosis. These findings allow for a new model of the study of left ventricle hypertrophy in postmenopausal osteoporosis that more closely mimics the natural progression of disease in female patients.

Funder

HHS | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) | Training Program for Innovative Engineering Research in Surgery and Intervention

U.S. Department of Veterans Affairs

Leducq Foundation

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00157.2022

Reference27 articles.

1. Heart Disease and Stroke Statistics—2021 Update

2. The Protective Effects of Estrogen on the Cardiovascular System