Relative flow of blood cells, platelets, and microspheres in outer and inner renal cortex

Author:

Ofjord E. S.,Clausen G.

Abstract

Blood platelets (Pl) may attain a relatively high marginal concentration in arterioles, perhaps also in arteries. Along a renal interlobular artery, blood passes several successive arterioles, each arteriole receiving a small flow fraction from a narrow zone adjacent to the artery wall. Thus, in theory, the Pl concentration should cumulatively decrease as the blood approaches the outer cortex, contrary to the concentration of red and white blood cells (RBC and WBC). This was tested by assessing the concentrations of these blood elements, and for comparison, the concentrations of 0.3-, 1.8- and 3.5-micron microspheres (MS), in serial blood samples from veins separately draining the outer and inner cortex in cat kidney. The outer-to-inner cortical concentration ratio was 1.28 for WBC, 1.04 for RBC, and 0.75 for Pl, confirming the working hypothesis. The RBC demargination corresponded to that of MS smaller than 1.8 micron, the demargination of WBC to that of MS larger than 3.5 micron. In contrast to Pl the even smaller 0.3-micron MS were not marginated. Thus, the margination of platelets may not be due merely to their small size.

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Microsphere skimming in the porcine coronary arteries: Implications for flow quantification;Microvascular Research;2015-07

2. Concentration profile of blood platelets differs in arterioles and venules;American Journal of Physiology-Heart and Circulatory Physiology;1992-04-01

3. Preferential distribution of leukocytes in rat mesentery microvessel networks;Pflügers Archiv - European Journal of Physiology;1988-07

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