Role of adropin in arterial stiffening associated with obesity and type 2 diabetes-Reference-Cited by-同舟云学术

Role of adropin in arterial stiffening associated with obesity and type 2 diabetes

Published:2022-11-01 Issue:5 Volume:323 Page:H879-H891
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Jurrissen Thomas J.¹²,Ramirez-Perez Francisco I.³^ORCID,Cabral-Amador Francisco J.³,Soares Rogerio N.³^ORCID,Pettit-Mee Ryan J.¹,Betancourt-Cortes Edgar E.³,McMillan Neil J.¹^ORCID,Sharma Neekun³,Rocha Helena N. M.²⁴^ORCID,Fujie Shumpei²⁵,Morales-Quinones Mariana³,Lazo-Fernandez Yoskaly³^ORCID,Butler Andrew A.⁶,Banerjee Subhashis⁶^ORCID,Sacks Harold S.⁷,Ibdah Jamal A.⁸⁹,Parks Elizabeth J.¹⁹^ORCID,Rector R. Scott¹⁸⁹,Manrique-Acevedo Camila²⁸¹⁰^ORCID,Martinez-Lemus Luis A.²³¹¹^ORCID,Padilla Jaume¹²⁸^ORCID

Affiliation:

1. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri

2. Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri

3. Department of Medicine, Center for Precision Medicine, University of Missouri, Columbia, Missouri

4. Department of Physiology and Pharmacology, Fluminense Federal University, Niteroi, Brazil

5. Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan

6. Department of Pharmacology and Physiological Sciences, Saint Louis University, Saint Louis, Missouri

7. Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California

8. Harry S. Truman Memorial Veterans’ Hospital, Columbia, Missouri

9. Division of Gastroenterology and Hepatology, Department of Medicine, University of Missouri, Columbia, Missouri

10. Division of Endocrinology and Metabolism, Department of Medicine, University of Missouri, Columbia, Missouri

11. Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri

Abstract

Arterial stiffening, a characteristic feature of obesity and type 2 diabetes (T2D), contributes to the development and progression of cardiovascular diseases. Herein we establish that adropin is decreased in obese and T2D models and furthermore provide evidence that reduced adropin may directly contribute to arterial stiffening. Collectively, findings from this work support the notion that “hypoadropinemia” should be considered as a putative target for the prevention and treatment of arterial stiffening in obesity and T2D.

Funder

Cardiometabolic Disease Research Fund

HHS | National Institutes of Health

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00385.2022

Reference76 articles.

1. Role of arterial stiffness in cardiovascular disease

2. Arterial Stiffness and Risk of Coronary Heart Disease and Stroke