Effects of nitric oxide inhalation on pulmonary arterial impedance: differences between normal and pulmonary hypertension male rats-Reference-Cited by-同舟云学术

Effects of nitric oxide inhalation on pulmonary arterial impedance: differences between normal and pulmonary hypertension male rats

Published:2024-07-01 Issue:1 Volume:327 Page:H287-H297
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Fukumitsu Masafumi¹^ORCID,Kawada Toru¹^ORCID,Nishikawa Takuya²,Yokota Shohei¹,Matsushita Hiroki¹,Morita Hidetaka¹,Sato Kei¹,Yoshida Yuki¹,Uemura Kazunori¹³^ORCID,Saku Keita¹³

Affiliation:

1. Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan

2. Department of Research Promotion and Management, National Cerebral and Cardiovascular Center, Osaka, Japan

3. NTTR-NCVC Bio Digital Twin Center, National Cerebral and Cardiovascular Center, Osaka, Japan

Abstract

Nitric oxide inhalation decreased pulmonary arterial impedance in the low-frequency range (<10 Hz) with little impact on the high-frequency range. It reduced peripheral pulmonary resistance more pronouncedly in pulmonary hypertension rats, whereas it increased arterial compliance and transmission time in control rats. Its effect on the mechanics of the pulmonary arteries may differ depending on the pathological status.

Funder

NTT Research

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00108.2024

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