The α2-isoform of the Na+/K+-ATPase protects against pathological remodeling and β-adrenergic desensitization after myocardial infarction-Reference-Cited by-同舟云学术

The α2-isoform of the Na+/K+-ATPase protects against pathological remodeling and β-adrenergic desensitization after myocardial infarction

Published:2021-10-01 Issue:4 Volume:321 Page:H650-H662
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Cellini Antonella¹²,Höfler Dorina¹²,Arias-Loza Paula A.¹³^ORCID,Bandleon Sandra¹²^ORCID,Langsenlehner Tanja⁴,Kohlhaas Michael¹^ORCID,Maack Christoph¹,Bauer Wolfgang R.²,Eder-Negrin Petra¹²^ORCID

Affiliation:

1. Comprehensive Heart Failure Center, Würzburg, Germany

2. Department of Internal Medicine I, University Hospital, Würzburg, Germany

3. Department of Nuclear Medicine I, University Hospital, Würzburg, Germany

4. Department of Therapeutic Radiology and Oncology, Medical University of Graz, Graz, Austria

Abstract

Reduced systolic and diastolic calcium levels in cardiomyocytes from NKA-α2 transgenic mice minimize the desensitization of the β-adrenergic signaling system. These effects result in an improved β-adrenergic reserve and prevent functional deterioration and cardiac remodeling.

Funder

Bundesministerium für Bildung und Forschung

Deutsche Forschungsgemeinschaft

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00808.2020

Reference46 articles.

1. Regulation of the cardiac sodium pump

2. Na+transport in cardiac myocytes; Implications for excitation-contraction coupling