Involvement of GPR37L1 in murine blood pressure regulation and human cardiac disease pathophysiology-Reference-Cited by-同舟云学术

Involvement of GPR37L1 in murine blood pressure regulation and human cardiac disease pathophysiology

Published:2021-10-01 Issue:4 Volume:321 Page:H807-H817
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Mouat Margaret A.¹²³^ORCID,Coleman James L. J.¹²³,Wu Jianxin³⁴,dos Remedios Cristobal G.³^ORCID,Feneley Michael P.⁴^ORCID,Graham Robert M.²³^ORCID,Smith Nicola J.¹²³^ORCID

Affiliation:

1. Molecular Pharmacology Laboratory, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia

2. St Vincent’s Clinical School, UNSW Sydney, Sydney, New South Wales, Australia

3. Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia

4. Cardiac Physiology and Transplantation Division, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia

Abstract

This study characterizes systolic blood pressure (SBP) in a Gpr37l1 knockout mouse line, which was previously reported to have ∼60 mmHg higher SBP compared with a transgenic line. We observed only a ∼27 mmHg SBP difference between the lines. However, when compared with C57BL/6J mice, knockout mice showed no difference in SBP. We also investigated GPR37L1 mRNA abundance in human hearts and observed no difference between healthy and failing heart samples.

Funder

National Heart Foundation of Australia

Australian Postgraduate Award

Simon and Michal Wilkenfeld Scholarship

Australian Government Research Training Program Scholarship

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00198.2021

Reference42 articles.