Progesterone promotes endothelial nitric oxide synthase expression through enhancing nuclear progesterone receptor-SP-1 formation-Reference-Cited by-同舟云学术

Progesterone promotes endothelial nitric oxide synthase expression through enhancing nuclear progesterone receptor-SP-1 formation

Published:2020-08-01 Issue:2 Volume:319 Page:H341-H348
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

You Yuehua¹,Tan Wanying¹,Guo Yongzheng¹,Luo Minghao¹,Shang Fei-fei²,Xia Yong¹²³,Luo Suxin¹²

Affiliation:

1. Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

2. Institute of Life Science, Chongqing Medical University, Chongqing, China

3. Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, Ohio

Abstract

Progesterone directly upregulated endothelial nitric oxide synthase (eNOS) expression in human endothelial cells. Progesterone augmented eNOS promoter activity through a progesterone receptor A- and specificity protein-1-dependent manner. Antagonism of the progesterone receptor reduced eNOS expression and impaired vasodilation in rats.

Funder

national program on key basic research project

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00206.2020

Reference41 articles.

1. Endothelium-derived nitric oxide and vascular physiology and pathology

2. Vascular Effects of Progesterone

3. Contragestion and Other Clinical Applications of RU 486, an Antiprogesterone at the Receptor