Tissue-specific small heat shock protein 20 activation is not associated with traditional autophagy markers in Ossabaw swine with cardiometabolic heart failure-Reference-Cited by-同舟云学术

Tissue-specific small heat shock protein 20 activation is not associated with traditional autophagy markers in Ossabaw swine with cardiometabolic heart failure

Published:2020-11-01 Issue:5 Volume:319 Page:H1036-H1043
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Silva Kleiton Augusto Santos¹^ORCID,Leary Emily V.²^ORCID,Olver T. Dylan³,Domeier Timothy L.⁴,Padilla Jaume⁵⁶,Rector R. Scott⁶⁷⁸,Emter Craig A.¹^ORCID

Affiliation:

1. Department of Biomedical Sciences, University of Missouri, Columbia, Missouri

2. Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri

3. Department of Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

4. Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri

5. Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri

6. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri

7. Division of Gastroenterology and Hepatology, Department of Medicine, University of Missouri, Columbia, Missouri

8. Research Service, Harry S Truman Memorial Veterans Medical Center, University of Missouri, Columbia, Missouri

Abstract

Our study shows that the activation of HSPB6 is tissue specific and associated with variable states of downstream markers of autophagy in a unique preclinical swine model of cardiometabolic HF with potential relevance to HFpEF. These findings suggest that targeted approaches could be an important consideration regarding the development of drugs aimed at this intracellular recycling process.

Funder

University of Missouri Research Board Grant

American Heart Association

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute on Aging

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00580.2020