Oxygen uptake kinetics and chronotropic responses to exercise are impaired in survivors of severe COVID-19-Reference-Cited by-同舟云学术

Oxygen uptake kinetics and chronotropic responses to exercise are impaired in survivors of severe COVID-19

Published:2022-09-01 Issue:3 Volume:323 Page:H569-H576
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Longobardi Igor¹^ORCID,Prado Danilo Marcelo Leite do¹,Goessler Karla Fabiana¹,Meletti Matheus Molina¹^ORCID,de Oliveira Júnior Gersiel Nascimento¹^ORCID,de Andrade Danieli Castro Oliveira²,Gualano Bruno¹²^ORCID,Roschel Hamilton¹²^ORCID

Affiliation:

1. Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, School of Medicine, University of São Paulo, São Paulo, Brazil

2. Rheumatology Division, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

Abstract

Our findings provide novel data regarding the impact of COVID-19 on submaximal and maximal cardiopulmonary responses to exercise. We showed that V̇o2 kinetics is significantly impaired at both the onset (on-transient) and the recovery phase (off-transient) of exercise in these patients. Furthermore, our results suggest that survivors of severe COVID-19 may have a higher metabolic demand at a walking pace. These findings may partly explain the exertional intolerance frequently observed following COVID-19.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de São Paulo

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00291.2022

Reference41 articles.

1. Extrapulmonary manifestations of COVID-19